The chaperone Glucose regulated protein 78 (GRP78), which is a central mediator of the unfolded protein response during endoplasmic reticulum (ER) stress, is a potential candidate for gene therapy in Dox cardiotoxicity for two reasons: First, it confers chemoresistance in certain tumors and tumor associated cell lines, while knockdown of GRP78 on the other hand resensitizes tumor cells to Dox [5, 6]. This evidence concerns the gene HSPA5 and neoplasm.