We screened forty-nine family members in forty-eight families for variants in one or more of the RCC causative genes VHL (n = 10), FH (n = 11), FLCN (n = 10), MET (n = 11) and SDHB (n = 9) and the putative RCC-genes BAP1 (n = 47), MITF (n = 46) and CDKN2B (n = 43). This evidence concerns the gene MITF and renal cell carcinoma.