VHL and renal cell carcinoma: In Denmark, patients with early onset RCC and families with accumulation of RCCs are usually screened for variants in four genes: VHL, FH, FLCN and MET. At Copenhagen University Hospital SDHB-screening is also performed, since pathogenic variants in SDHB are correlated with an increased risk of paraganglioma, pheochromocytoma and RCC and standard chromosome analysis is performed to examine for the known chromosome translocation t(3;8)(p14.2;q24.1).