When we analysed the role of Cdc42 on EGFR stability in gastric cancer cells, we observed that the silencing of Cdc42 impaired MICAL‐L2‐induced EGFR up‐regulation and active form of Cdc42 significantly rescued the attenuated EGFR expression in MICAL‐L2‐depletion cells. Here, EGFR is linked to gastric cancer.