Key regulatory proteins of the actin cytoskeleton such as WASP family proteins, Arp2/3 complex, LIM‐kinase, cofilin linked the formation of invasive protrusions in cancer cells.2 MIIP is also thought to contribute in the decreased formation of lamellipodia in endometrial carcinoma cell migration via Rac1.3 In recent studies, molecules interacting with CasL (MICALs) were reported to participate in cytoskeleton dynamics.4, 5, 6 The homo sapiens MICAL family consists of three MICAL proteins, (MICAL1‐3) and two MICAL‐L homologues (MICAL‐L1,‐L2). The gene discussed is MICAL1; the disease is endometrial carcinoma.