This result is similar to our previous report that MICAL1, via promoting ROS production by its MO domain, controls breast cancer cell invasive phenotype.26 As MICAL‐L2 lacks the MO domain involved in F‐actin oxidation and disassembly, the mechanisms underlying the potentiation of gastric cancer cell migration might be different with other MICAL proteins. Here, MICAL1 is linked to breast cancer.