SMARCB1 and neoplasm: SMARCB1 therefore appears to function largely as a transcriptional repressor in hESCs, particularly at bivalent genes, in contrast to what has been reported in experiments in mouse embryonic fibroblasts (MEFs) and several null tumor cell lines, including TTC-1240 (Wang et al., 2017; Nakayama et al., 2017; Wilson et al., 2010).