THBD and neoplasm: Myeloid cell reprogramming, a common feature of the TME, is known to be a continuous differentiation process.34 Depending on specific cues from the TME, monocytes can differentiate into inflammatory macrophages (M1 macrophages), monocyte‐derived DCs (CD1c+ or CD141+ DC) with anti‐tumor immune functions, or alternatively activated macrophages (M2 macrophages) with immunosuppressive properties (Figure 2).