When the mice were treated with the water replete diet, a majority of NFAT5 was localized in the cytosol in the inner medulla of SCD mice as estimated by only 26.5% of cells having concentrated NFAT5 nuclear staining as opposed 87% of cells having similar staining in the non‐SCD inner medulla (Fig. 6). Here, NFAT5 is linked to Schnyder corneal dystrophy.