AQP2 and Schnyder corneal dystrophy: 2013). The un‐expected increase of AQP2 protein abundance prompted us to examine whether SCD trapped AQP2 in the cytoplasm of the inner medullary collecting ducts. A majority of AQP2 was localized in both apical and basolateral regions of the collecting ducts of non‐SCD mice because of the mice were fed with a water replete diet (Figure 3A and C). In contrast, most of AQP2 was in fact concentrated in the apical region of the collecting ducts of SCD mice fed with the same diet (Figure 3B and C).