With these mice, we sought to determine whether SCD reduced urinary vasopressin level, protein levels of AQP2, NKCC2, UTA1, and ENaC, and inhibited NFAT5 transcriptional activity, and whether SCD dampened the response of these channels, transporters and transcription factor to water‐restriction. The gene discussed is NFAT5; the disease is Schnyder corneal dystrophy.