Although direct functional evidence is lacking, the increased protein abundance of AQP2, UTA1, ENaC‐β and possible NKCC2, and apical targeting of AQP2 under the water replete condition (Figs. 2 and 3), and no statistical difference in expression of AQP2 and NKCC2 protein levels and in AQP2‐S256‐P and AQP2 apical targeting in response to water restriction from the non‐SCD mice (Figs. 3and 4) indicate that the kidney medullary tubules of SCD mice preserve the ability responding to vasopressin and water restriction. The gene discussed is SLC12A1; the disease is Schnyder corneal dystrophy.