However, despite lack of a significant effect on the urinary vasopressin level, water restriction still significantly augmented AQP2 protein level by 57% and NKCC2 by 48% in the outer medulla of SCD mice on the top of already increased protein abundance of AQP2 and NKCC2 under water repletion. Here, AQP2 is linked to Schnyder corneal dystrophy.