However, despite lack of a significant effect on the urinary vasopressin level, water restriction still significantly augmented AQP2 protein level by 57% and NKCC2 by 48% in the outer medulla of SCD mice on the top of already increased protein abundance of AQP2 and NKCC2 under water repletion. The gene discussed is SLC12A1; the disease is Schnyder corneal dystrophy.