Previous studies indicate that Grx3, especially the C‐terminal region of Grx3, can physically interact with a muscle LIM protein (MLP) to prevent the formation of the MLP–calcineurin complex, and thus blocking calcineurin–NFAT signaling associated with the development of cardiac hypertrophy under pressure overload (Jeong et al. Here, GLRX3 is linked to cardiac hypertrophy.