2014) and oxidized cardiac ryanodine receptor (RyR2) contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure (Terentyev et al. 2008). Therefore, there is possibility that Ca2+ handling problem could be caused by ROS‐mediated oxidative stress in Grx3 CKO mice, which warrants future investigation. The gene discussed is GLRX3; the disease is congestive heart failure.