RYR2 and congestive heart failure: 2014) and oxidized cardiac ryanodine receptor (RyR2) contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure (Terentyev et al. 2008). Therefore, there is possibility that Ca2+ handling problem could be caused by ROS‐mediated oxidative stress in Grx3 CKO mice, which warrants future investigation.