ALDOB and hepatocellular carcinoma: In addition, ALDOB and multiple miRNAs, some of which are up‐regulated in HCC, have been demonstrated to directly target TET proteins.53, 54, 55, 57, 64 Decreased expression of TET proteins and lower 5hmC levels are general hallmarks of multiple cancer types, including HCC.18 These pieces of evidence imply that miRNA repression or substitution might offer us a novel therapeutic approach to inhibit HCC invasion and distant metastasis.