MTOR and hepatocellular carcinoma: PI3K signalling regulates lysosomal maturation, size and activity and is involved in the control of lysosomal stability,38, 39, 58 and PI3K/mTOR inhibitors were reported to cause LMP.39, 59, 60, 61 In this study, we showed that cisplatin combined with the dual PI3K/mTOR inhibitor PKI‐402 induced LMP in HCC cells.