After exposure to cisplatin for 12 and 24 hours, the mitophagy‐related proteins PINK1, parkin and LC3‐II/I were upregulated in HCC cells; the mitophagy substrate p62 was downregulated; and the lysosomal surface proteins LAMP1, cathepsin B and cathepsin D were upregulated. The gene discussed is CTSB; the disease is hepatocellular carcinoma.