Furthermore, PKI‐402 combined with cisplatin significantly increased the number of lysosomes, which may be associated with the inhibition of mTOR by PKI‐402 and the alleviation of the inhibition of TFEB64; this effect increases the quantity of lysosomes in HCC cells and enhances the killing effect of LMP. This evidence concerns the gene PDLIM7 and hepatocellular carcinoma.