CCR3 and ovarian neoplasm: Apart from CCL22, CCL28 produced by ovarian tumour cells under hypoxia has also been implicated in the preferential recruitment of Treg cells, both in in vitro migration assays using mouse and human Treg cells and in an in vivo model of ascitic ovarian tumours.85 CCR10, rather than CCR3, was shown to be the receptor involved in this effect.