SCN5A and Brugada syndrome: Studies aiming to recapitulate the response of Brugada syndrome patients to pro- and anti-arrhythmic drugs showed that in Langendorff-perfused Scn5a+/− hearts, flecainide increased RV transmural gradients while quinidine decreased them, in line with their respective pro- and antiarrhythmic effect [29,30,31].