Our results also suggest that the reduction of PMP22 proteins in Nf1fl/fl;DhhCre mouse neurofibromas may be attributed not only to reduced transcriptional regulation but also possibly to loss of RNA stability and diminished rate of posttranscriptional and/or translational modification in neurofibroma SCs, and further experiments are needed to determine whether and how these posttranscriptional steps are involved in regulating PMP22 protein expression. The gene discussed is PMP22; the disease is plexiform neurofibroma.