No significance was detected on survival time between RunxWT;Runx3WT;Nf1fl/fl;DhhCre and Runx1fl/+;Runx3fl/+;Nf1fl/fl;DhhCre mice, suggesting that loss of each allele of Runx1 and Runx3 only might not change tumor penetration rate. Here, RUNX1 is linked to neoplasm.