It is different from the Runx1 genetically conditional knockout, in which RUNX1 has no function but CBFB function is undisturbed, and the compensated Runx3 gene produces RUNX3 that can bind to CBFB to achieve RUNX transcriptional activities and contribute to neurofibroma formation. The gene discussed is RUNX1; the disease is plexiform neurofibroma.