To demonstrate the functional activation of cell survival signaling in NSCLC cells with overexpression of GPX1, expression levels of BLC2 and Bax were analyzed by western blot in cell lines (H460 and H1650) with forced overexpression of GPX1 and in cell lines (A549 and H1975) with siRNA-knockdown expression of GPX1. The gene discussed is GPX1; the disease is non-small cell lung carcinoma.