To elucidate the upstream signaling regulating GPX1 expression in NSCLC cells, we proceeded to examine the role of NF-κB in regulation of GPX1 expression in NSCLC cell lines (A549 and H1975) with elevated expression of GPX1 as well as in development of cisplatin-based chemoresistance of NSCLC. This evidence concerns the gene GPX1 and non-small cell lung carcinoma.