For example, the etiological lncRNA changes associated with major depressive disorder include the cognitive disorders-related lncRNAs RNON, HAR1, PACER, and BACE1-AS; synaptic plasticity-related lncRNAs BDNF-AS, DISC2, and BC200; or lncRNAs related to other psychiatric diseases such as GOMAFU and MALAT-1 [23]. This evidence concerns the gene BDNF and Cognitive impairment.