There were no significant differences in the genotype distribution of TIMP-2 (-418G/C) between acne patients and normal controls (GG, GC, and CC genotype distributions as follows: 68.1%, 27.8%, and 4.8% in acne patients versus 73.6%, 23.9%, and 2.5% in normal controls) (Table 3). Here, TIMP2 is linked to acne.