CT70 and atherosclerosis: For example, the lncRNA LeXis regulates hepatic lipid accumulation and plasma cholesterol levels, and thereby decreases atherogenesis in Ldlr knockout mice (63), and MeXis, a lncRNA that is highly expressed in mouse macrophages, promotes macrophage cholesterol efflux, HDL-driven reverse cholesterol transport, and thus reduces macrophage foam cell formation and atherosclerosis development (64).