Previous studies showed that DEPDC1 inhibited the transcription of A20 through NF-κB pathway in bladder cancer, hepatic carcinoma, lung cancer, and nasopharyngeal carcinoma, which acted a key role in cell proliferation, tumorigenesis and metastasis (10, 15, 18, 26, 27, 34). The gene discussed is DEPDC1; the disease is hepatocellular carcinoma.