NTRK1 and neoplasm: Drilon et al. used a non-comparative, genomic-driven, single-arm basket trial in 55 patients with TRK translocations across 12 different tumor types, and found that the ORR of larotrectinib (LOXO-101, a TRK inhibitor) was 80%, and 71% of the responses were still ongoing at 1 year (49).