NR1H3 and early-onset autosomal dominant Alzheimer disease: Nevertheless, we should note that rs3792646 was also present in the general population (with an allele frequency ranging from 0.0004–0.03), leading to an argument against its pathogenic status, similar to the case of NR1H3 p.R415Q in multiple sclerosis [77], although the situation in Alzheimer's disease might be a bit different, partly due to its late age-of-onset.