Consistently, we observed an early increase and a strong positive correlation of C1q and C3 mRNA expression level with the severity of pathological changes (Aβ plaques and tau tangles) in the hippocampus of Alzheimer's disease mouse models based on the Mouseac database (www.mouseac.org) [59] (Supplementary Fig. S3; C7 was unfortunately not included in this dataset). Here, MAPT is linked to Alzheimer disease.