Moreover, in the model of αGalCer induced immune-mediated hepatitis, in which liver injury is independent of hepatic macrophages/ monocytes, mirtazapine treatment did not alter hepatitis severity as reflected by ALT levels (ALT in U/L; vehicle: 19.0 ± 1.1 vs. αGalCer + vehicle: *251.4 ± 29.8 vs. αGalCer + mirtazapine: *271.0 ± 61.7; *p < 0.01 vs. vehicle alone group; n = 5 mice per group). Here, GPT is linked to Hepatitis.