Moreover, these findings reveal for the first time the role of some cytokines that had not been related to ALS yet, including chemokines belonging to the tumor necrosis factor (TNF) and tumor necrosis factor receptor (TNFR) superfamilies (CD30 L, GITR, TRANCE, TROY), chemokine ligands family (6Ckine, MIP-3β) and other cytokines (ALK-1, VEGF-D). This evidence concerns the gene TNF and amyotrophic lateral sclerosis.