PTX3 and Sepsis: Interestingly, in addition to being effective against opportunistic bacteria known to be responsible of sepsis (e.g., K. pneumoniae and P. aeruginosa), PTX3 was shown to have protective effect by reducing the mortality in mouse models of sepsis induced by histone infusion, LPS-induced endotoxemia and cecal ligation and puncture, through its N-terminal domain (25, 26).