Here, our current study provides novel findings, emphasizing the need for both TNBC:MSC cross-talk and pro-inflammatory signals delivered by TNFα and IL-1β, in order to achieve the most substantial levels of pro-metastatic activities: high levels of pro-metastatic chemokines, CXCL8, CCL2 and CCL5, angiogenesis, and tumor cell migration and invasion. This evidence concerns the gene CXCL8 and neoplasm.