IL1B and neoplasm: Despite the fact that TNFα and IL-1β induced potent p65 and JNK activation in T47D and MCF-7 luminal-A cells (Figures 6A, 7A), CXCL8 levels were not increased but rather were decreased when the tumor cells interacted with MSCs in the presence of TNFα and IL-1β (Figures 6B1, 7B).