TNF and colitis: Dietary anti-inflammatory polyphenols, such as chlorogenic acid and resveratrol, significantly suppressed the secretion of several cytokines (interferon gamma IFN-γ, tumor necrosis factor alfa TNF-α), reduced the colonic infiltration of CD3+T cells producing these cytokines and neutrophils in colitis and in colitis-associated to CRC experimental model (74, 75).