MT-ND1 and neoplasm: Lipid binding by NaD1 and other defensins occurs at NaCl concentrations of 100 mM and higher (Payne et al., 2016) and the tumor cell killing activity of NaD1, which is more dependent on lipid binding than the antifungal activity (Bleackley et al., 2016), also occurs at elevated concentrations of NaCl.