Despite the lack of GLP-1R expression, GLP-1RAs appear to have a positive effect on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH), as evidenced by a clinical trial with liraglutide and now under further investigation in clinical trials with semaglutide (109, 110). Here, GLP1R is linked to metabolic dysfunction-associated steatotic liver disease.