SNCA and synucleinopathy: Recently, the identification of α-synuclein deposits in skin biopsies has opened a window to better understand autonomic denervation, as well as providing a sensitive and specific biomarker for early diagnosis of the α-synucleinopathies, with a strong correlation between α-synuclein load in cutaneous small fibers and measures of cardiovascular autonomic function, and skin pilomotor and sudomotor responses (10, 14–17).