In potential support of this, one of WHSC1’s more established roles is that of an H3K36 methyltransferase, an epigenetic regulator that has been billed as oncogenic, given high levels of dysregulation in some cancer tissues (Huang et al., 2013; Kuo et al., 2013), and its potential to orchestrate transcriptional programs that drive unchecked proliferation (Park et al., 2018). This evidence concerns the gene NSD2 and cancer.