NSD2 and neoplasm: Other studies report its function to be that of a tumor suppressor, given its high mutation rate in lymphomas (Beà et al., 2013; Zhang et al., 2014); additionally, whsc1 knockout or depletion in zebrafish demonstrated enlarged hearts, brains, and predisposition to swim bladder tumors (Yamada-Okabe et al., 2010; Yu et al., 2017), suggesting unchecked expansion of developmental progenitors.