NOS3 and Hyperglycemia: The same occurs in obesity and experimental models of diabetes, in which insulin resistance and hyperglycemia culminate in increased NAD(P)H oxidase enzyme activity and endothelial nitric oxide synthase (eNOS) uncoupling, thereby contributing to increased ROS generation and impaired vascular function (Youn et al., 2012; da Costa et al., 2017; Neves et al., 2018).