RPTN and myocardial ischemia: The administration of rMK and rPTN has been proposed in a number of CNS and peripheral injuries, rending already significant effects in preclinical models, particularly in the case of myocardial ischemia (Christman et al., 2005b; Fukui et al., 2008) and bone repair (Lamprou et al., 2014; Liedert et al., 2014).