NQO1 and colitis: This beneficial effect was also observed on DSS-induced murine colitis, and a molecular mechanism study further revealed that sinomenine (100 mg/kg of body weight in mice, p.o.)could markedly increase the expression of Nrf2 and its downstream genes, heme oxygenase-1 and NADP(H) quinone oxidoreductase 1 (NQO-1) (Zhou et al., 2018).