In his oxazolone-induced murine colitis paper, He et al. (2012) reported that treatment with tetramethylpyrazine (100 mg/kg of body weight in mice, i.p.)significantly improves the colonic inflammatory status, decreases the expression of colonic TNF-α, iNOS, NF-κB p65 and COX-2, and increases PPAR-γ production. This evidence concerns the gene TNF and colitis.