WWC1 and Alzheimer disease: In addition, KIBRA is involved in multiple cellular functions such as synaptogenesis, vesicle transport, transcriptional regulation, cell polarity and migration through interacting with diverse partners, which also play crucial roles in the pathogenesis of AD (Hilton et al., 2008; Xiao et al., 2011; Yoshihama et al., 2011, 2012; Ji et al., 2012).