Some clinical and animal studies have also found a significant interaction between sex and Cacna1c genotype (Dao et al., 2010; Witt et al., 2014; Takeuchi et al., 2018); for instance, female, but not male, Cacna1c heterozygous mice have been shown to display decreased risk-taking behavior and increased anxiety in multiple tests (Dao et al., 2010). Here, CACNA1C is linked to Anxiety.