Immunoblotting using antibodies that specifically recognize phosphorylated epitopes (notably serines S403, S404, S409, S410) in the C-terminal domain of TDP-43 consistently detects CTF-25 in the brains of both FTLD-TDP and ALS patients (Hasegawa et al., 2008; Inukai et al., 2008; Neumann et al., 2009; Arai et al., 2010; Tsuji et al., 2012a,b, Kametani et al., 2016; Watanabe et al., 2018). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.