TARDBP and amyotrophic lateral sclerosis: TDP-43 CTFs transfected in immortalized cell lines were phosphorylated at the same or very similar sites to those seen in ALS and FTLD patient tissue and formed insoluble inclusions (Igaz et al., 2009; Zhang et al., 2010; Furukawa et al., 2011; Li et al., 2011).