TARDBP and frontotemporal dementia: Determining how the distinct gene and protein profiles of various classes of neurons renders certain populations susceptible to TDP-43 pathology or specific post-translational TDP-43 modifications may assist in understanding the complex biology of TDP-43 in diseases such as ALS and FTD that are characterized by dramatic genetic, neuropathological and phenotypic heterogeneity (Simon et al., 2014), and elucidate protective molecular and cellular factors for therapeutic targeting.