TARDBP and amyotrophic lateral sclerosis: When expressed in cultured neuronal cells, fragments from the C-terminal portion of TDP-43 form ubiquitinated, phosphorylated inclusions that closely resemble human ALS and FTLD-TDP brain pathology (Igaz et al., 2009; Nonaka et al., 2009; Zhang et al., 2009, 2010; Yang et al., 2010; Fallini et al., 2012; Chou et al., 2015; Kitamura et al., 2016).