However, in the cortex of ALS and FTLD patients where CTFs predominate, stress granule markers do not co-localize with TDP-43 inclusions (Bentmann et al., 2012) or show a lower degree of specificity than in ALS spinal cord tissue (Liu-Yesucevitz et al., 2010). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.