In Drosophila, transgenic expression of full-length TDP-43 or ALS/FTLD-linked mutations has been shown to shorten overall lifespan (Voigt et al., 2010) and exacerbate age-dependent reductions in fly motility (Li et al., 2010) more dramatically than expression of TDP-43 CTFs. Here, TARDBP is linked to amyotrophic lateral sclerosis.