Indeed, the C-terminal domain of TDP-43 is enriched with serine residues, and phosphorylation of this region is widely observed in tissue from ALS and FTLD patients (Hasegawa et al., 2008; Inukai et al., 2008; Kametani et al., 2009; Neumann et al., 2009). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.