TARDBP and amyotrophic lateral sclerosis: Despite the post-mortem evidence for the presence of TDP-43 CTFs in both the ALS and FTLD brain, structural magnetic resonance imaging as well as post-mortem analysis reveals widespread brain atrophy in FTLD (Broe et al., 2003; Consonni et al., 2018; Sellami et al., 2018), whereas patients with ALS exhibit milder, focal thinning of the primary motor and pre-motor cortices and damage to the corticospinal tract (Roccatagliata et al., 2009; Chen and Ma, 2010; Verstraete et al., 2012).