Consistent with the memory impairments observed in these mouse models, TDP-43 CTFs arising from caspase cleavage at residue 219 have been detected in neurofibrillary tangles, Hirano bodies and reactive astrocytes in the hippocampus and entorhinal cortex of people with Alzheimer’s disease at post-mortem (Rohn, 2008). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.