A Drosophila model of FUS-linked ALS has shown that this RNA-binding protein undergoes phase-transitioning into solid aggregates due to its prion-like binding domain and interactions with arginine-rich domains (Bogaert et al., 2018) and the effect of this on MND phenotypes and possible reversal of the transition has been further studied. Here, FUS is linked to amyotrophic lateral sclerosis.