Further variable members of the NPC were found to be ALADIN (AAAS) (p = 0.12, one-sided t test), which potentially binds to transmembrane nucleoporins and has been linked to genetic disease, as well as NUP50 (FDR-corrected p = 0.022, one-sided t test), a subunit involved in active nuclear import (Beck and Hurt, 2017). This evidence concerns the gene NPC1 and hereditary disease.