ABCB1 and cancer: Due to the low toxicity of resveratrol in vivo as well as in vitro and its anti-leukemic effects, being selective of its effects and be useful as an anti-leukemic agent; We decided to assess the effect of resveratrol and prednisolone on overcoming drug resistance caused by increased expression and function of MDR1 by changing its expression and reducing its expression in CCRF-CEM cancer cells.