BCL2 and cancer: Our observation on these acute lymphoblastic cells CCRF-CEM also showed that resveratrol and prednisolone can increase the apoptosis of these cancer cells by changing the expression of microRNAs miR 15a and miR16-1 and also reducing the expression of BAX gene as well as increasing expression of BCL-2 without changing the pattern of methylation of the promoter of BAX and BCL-2 genes (Azimi et al., 2015; Azimi et al., 2016; Heydarabad et al., 2016; Zadi Heydarabad et al., 2018; Zadi Heydarabad et al., 2018).