GE can also induce methylated BTG3 promoter expression in human prostate carcinoma cell lines (LNCaP, PC3), increase levels of acetylated histones 3, 4, histone 3 trimethylated at lysine 4, histone 3 dimethylated at lysine 4, RNA polymerase II and decrease DNA methyl transferase and methyl-binding domain protein 2 activity, and increase histone acetyl transferase (HAT) activity (Majid et al., 2010). Here, TMPRSS11D is linked to prostate carcinoma.