GE can reverse DNA hypermethylation and reactivates p16INK4a, RARb and MGMT in KYSE 510 esophageal squamous cell carcinoma cells, KYSE 150 cells, prostate cancer LNCaP and PC3 cells (Fang et al., 2005). This evidence concerns the gene CDKN2A and esophageal squamous cell carcinoma.