MUC16 and ovarian cancer: CA-125 is not very sensitive at detecting early-stage ovarian cancer and demonstrates lower specificity as CA-125 is often elevated in benign gynecological conditions (Meden and Meibodi, 1998; Ismail et al., 1994; Cheng et al., 2002; Kitawaki et al., 2005; Abrao et al., 1999).