Decreased expression of DUSP4, a negative regulator of extracellular signal-regulated kinases (ERK), is related to high RAS-ERK activation and has been recently identified as a mediator of resistance to neoadjuvant chemotherapy in triple-negative breast cancer, promoting to a shorter recurrence-free survival (Balko et al., 2012; Rottenberg and Jonkers, 2012). This evidence concerns the gene DUSP4 and triple-negative breast carcinoma.