MTOR and autoimmune disease: Therefore, the quality of fat, including reduced ratio of the ω6 /ω3 fatty acids or intake increase of ɷ3-PUFAs, as well as administration of rapamycin (RAPA), can ameliorate autoimmune diseases by inhibiting T-helpers: Th1/Th2/Th17 cells and up-regulating of Treg cells via the control of mTOR signaling in autoimmune diseases (Sakaguchi, 2004; Yuan et al., 2015; Rezapour-Firouzi, 2017).