PLA2G2D and cancer: The role of sPLA2s in cancer has been generally associated with their enzymatic activity and the ability to participate in the release of an effective biologically active lipid mediator, exactly AA-derived eicosanoids such as PGE2, promoting tumor igenesis by stimulating cell proliferation and cell survival through abolishing apoptosis and increasing local inflammation and angiogenesis (Brglez et al., 2014).