Thus, expression of tuberous sclerosis complex (TSC)-1 was reduced in individuals with severe 25D deficiency (< 25 nmol/l; n = 5 (n = 2 healthy controls/n = 3 stable MS patients)) compared to individuals with 25D levels between 25–49.9 nmol/l (deficient; n = 42 (n = 24 healthy controls/n = 18 stable MS patients)) or with sufficient levels (≥ 50 nmol/l; n = 65 (n = 37 healthy controls/n = 28 stable MS patients); Fig. 5b). This evidence concerns the gene TSC1 and myeloid sarcoma.