To investigate the role of Nestin+ and Nestin− BMSCs in myocardium repair post-MI, C57BL/6 mice were randomly divided into three groups, a saline control group, a Nestin+ BMSC group, and a Nestin− BMSC transplantation group, and underwent permanent ligation of the LAD coronary artery. The gene discussed is NES; the disease is myocardial infarction.