Based on the lack of pNDRG1 signal in a nerve from the NDRG1mut/mut Alaskan malamute, we propose that disease-causing mutations in NDRG1 can disrupt signaling events in myelinating Schwann cells, leading to disturbance in the myelin homeostasis and axonal-glial cross talk, thereby precipitating polyneuropathy. This evidence concerns the gene NDRG1 and polyneuropathy.