Osimertinib is a third-generation EGFR TKI, designed to overcome resistance due to T790M and representing the current standard treatment for advanced, T790M-positive NSCLC patients progressing after first or second- generation EGFR TKI (Cross et al. 2014; Ramalingam et al. 2018). Here, EGFR is linked to non-small cell lung carcinoma.