These include (i) immune-suppressive cells like Treg cells and myeloid-derived suppressive cells, (ii) anti-inflammatory cytokines like tumor growth factor (TGF)-β and IL-10, (iii) defective antigen presentation by tumor cells because of antigen expression loss and antigen processing defects, (iv) immune inhibitory molecules like CTLA-4 and PD-1, and (v) amino acid–catabolizing enzymes like arginase and indoleamine-2-3 dioxygenase (IDO) [157]. The gene discussed is CTLA4; the disease is neoplasm.