TYK2 and psoriasis: Regarding the latter (see also below), psoriasis has been linked for example to polymorphisms within IL12B, IL23A, IL23R, and, in some patients with a special psoriasis subtype, pustular psoriasis, also IL36RN. Moreover, there are associations with variants in REL, TYK2, RUNX3, STAT3, and TRAF3IP2 [115].