Based on these criteria, we identified nonsynonymous coding variants in several genes associated with chromatin structure modification and epigenetic regulation (TET2, DNMT3A, KMT2C, KMT2D, SETD2, CREBBP), tumor suppression (FAT1, LATS1, STK3, TP53, TP63, ATM), and NOTCH signaling (NOTCH1, NOTCH2) (Fig. 1c). This evidence concerns the gene NOTCH1 and neoplasm.