We also observed genomic alterations in other members of the canonical Hippo pathway, including LATS1, and SKT3/MTS-2, although at a lower frequency than those affecting FAT1. These results suggest that the presence of somatic mutations in FAT1 and Hippo core molecules might represent an important event at least in a percentage of peripheral T-cell lymphomas not otherwise specified, irrespective of the subgroup (GATA3 or TBX21-related) they belong to. Here, TBX21 is linked to peripheral T-cell lymphoma, not otherwise specified.