The next generation sequencing approach has recently led to the discovery of recurrent somatic mutations of genes involved in the epigenetic regulation (KMT2D, TET2, KDM6A, DNMT3A, CREBBP, KMT2A), signaling pathways (TNFAIP3, APC, CHD8, ZAP70, NF1, TNFRSF14, TRAF3), and tumor suppression (TP53, FOXO1, BCORL1, ATM) [5–7]. The gene discussed is KMT2D; the disease is neoplasm.