TP53 and neoplasm: The next generation sequencing approach has recently led to the discovery of recurrent somatic mutations of genes involved in the epigenetic regulation (KMT2D, TET2, KDM6A, DNMT3A, CREBBP, KMT2A), signaling pathways (TNFAIP3, APC, CHD8, ZAP70, NF1, TNFRSF14, TRAF3), and tumor suppression (TP53, FOXO1, BCORL1, ATM) [5–7].