These findings of class switching of IgM antibodies to IgG antibodies and affinity maturation for different matured ZIKV proteins suggest that immune dominance following infection is determined by multiple factors including protein concentration, BCR affinity, antigen processing by B cells, presentation to TFH cells and germinal center (GC) entry, which is required for class switching and affinity maturation41-44. This evidence concerns the gene CD40LG and infection.