Nobiletin reduces cerebral ischemic injury by upregulating nuclear factor (erythroid-derived 2)-like-2 (Nrf2) and HO-1, attenuates IR injury following liver transplantation through the suppression of Kupffer cell activation, and protects against acute myocardial infarction by restoring impaired autophagic flux19,22,23. Here, NFE2L2 is linked to acute myocardial infarction.