The RyR2-P2328S mutation produces catecholaminergic polymorphic ventricular tachycardia (CPVT) and AF in hearts from homozygous RyR2P2328S/P2328S (denoted RyR2S/S) mice. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.