Reduced FKBP12.6 binding to recombinant RyR2 channels has been reported with P2328S, S2226L, R2474S and R4497C CPVT mutations (Lehnart et al., 2008; Wehrens et al., 2003), and increasing FKBP12.6 association with RyR2 can prevent aberrant SR Ca2+ release with AF and CPVT (Meli et al., 2011; Shan et al., 2012; Wehrens et al., 2003). This evidence concerns the gene RYR2 and atrial fibrillation.