We find that FKBP12 and FKBP12.6 (hereafter FKBP12/12.6) removal from sheep RyR2 is correlated with increased sub-conductance activity in one RyR2 channelopathy linked to a mutation in the RyR2-associated regulatory protein CLIC-2 (Richardson et al., 2017). The gene discussed is FKBP1A; the disease is channelopathy.