Conversely, the CPVT R2474S RyR2 demonstrated increased FKBP12.6 affinity (Tiso et al., 2002), while enhanced FKBP12.6 binding did not alter arrhythmias in R4496C mice (Liu et al., 2006). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.